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The Institutional Review Board (IRB) regulates all research activities involving human subjects on the UT Knoxville campus. The IRB is a committee appointed to ensure rights, safety, and welfare of human research subjects; ensure compliance with all applicable federal and state laws/regulations; and conduct ethical reviews of human research activities including initial, continuation, modification, unanticipated problems and alleged noncompliance. Its primary responsibility is to assure UT Knoxville researchers operate within the provisions of the Federalwide Assurance of Compliance filed with the U.S. Department of Health and Human Services (DHHS) Office for Human Research Protections (OHRP).

All IRB applications must be submitted through iMedRIS. 

Do you need help submitting your IRB application via iMedRIS? You can find helpful guides and instructions for navigating the iMedRIS application process here. For more information on iMedRIS, visit the Office of Research and Engagement’s resource page.

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